Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline

Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline

The syntheses of three malagashanine analogues are reported. They involve conversion of strychnobrasiline in multiple steps and obtaining (i) unsaturation of the bond 3–14, (ii) inversion of configuration on carbon C3, (iii) inversion of configuration on carbon C3 and reduction of the benzene ring....

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Veröffentlicht in:Tetrahedron 2004-06, Vol.60 (25), p.5471-5474
Hauptverfasser: Trigalo, François, Joyeau, Roger, Pham, Van Cuong, Youté, Jean Jacques, Rasoanaivoa, Philippe, Frappier, François
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloid
Biochemistry
Biochemistry, Molecular Biology
Life Sciences
Malagashanine
Reductive amination
Strychnobrasiline
Strychnos myrtoı̈des
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Zusammenfassung:The syntheses of three malagashanine analogues are reported. They involve conversion of strychnobrasiline in multiple steps and obtaining (i) unsaturation of the bond 3–14, (ii) inversion of configuration on carbon C3, (iii) inversion of configuration on carbon C3 and reduction of the benzene ring. Graphic
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2004.04.068