Electrical Control of Protein Conformation

Electrical Control of Protein Conformation

Conducting polymer devices that enable precise control of fibronectin conformation over macroscopic areas are reported. Single conformations as well as conformation gradients are achieved by applying an appropriate potential. These surfaces remain biologically relevant and support cell culture; henc...

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Veröffentlicht in:Advanced materials (Weinheim) 2012-05, Vol.24 (18), p.2501-2505
Hauptverfasser: Wan, Alwin M. D., Schur, Rebecca M., Ober, Christopher K., Fischbach, Claudia, Gourdon, Delphine, Malliaras, George G.
Format: Artikel
Sprache:eng
Schlagworte:
3T3 Cells
Animals
Bridged Bicyclo Compounds, Heterocyclic - chemistry
Electricity
Engineering Sciences
fibronectin
Fibronectins - chemistry
Fibronectins - metabolism
Fluorescence Resonance Energy Transfer
Mice
Micro and nanotechnologies
Microelectronics
organic bioelectronics
Polymers - chemistry
Protein Conformation
Regenerative Medicine
Surface Properties
Tissue Engineering
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Beschreibung
Zusammenfassung:Conducting polymer devices that enable precise control of fibronectin conformation over macroscopic areas are reported. Single conformations as well as conformation gradients are achieved by applying an appropriate potential. These surfaces remain biologically relevant and support cell culture; hence, they may serve as a model to understand and control cell‐surface interactions, with applications in basic research, medical diagnostics, and tissue engineering.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201200436