Insulin growth factor-1 protects against excitotoxicity in the rat striatum

Recent findings demonstrated the neuroprotective effects of insulin-like growth factor 1 (IGF-1) in a cultured cell model of Huntingtonʼs disease. In the present study, we examined the potential neuroprotective effect of IGF-1 in vivo, in a rat model of Huntingtonʼs disease using the NMDA receptor a...

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Veröffentlicht in:	Neuroreport 2004-10, Vol.15 (14), p.2251-2254
Hauptverfasser:	Escartin, Carole, Boyer, Frédéric, Bemelmans, Alexis-Pierre, Hantraye, Philippe, Brouillet, Emmanuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Corpus Striatum - drug effects Corpus Striatum - metabolism Excitatory Amino Acid Agonists - toxicity Insulin-Like Growth Factor I - biosynthesis Insulin-Like Growth Factor I - pharmacology Life Sciences Male Neurons and Cognition Neuroprotective Agents - pharmacology Quinolinic Acid - toxicity Rats Rats, Sprague-Dawley
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Zusammenfassung:	Recent findings demonstrated the neuroprotective effects of insulin-like growth factor 1 (IGF-1) in a cultured cell model of Huntingtonʼs disease. In the present study, we examined the potential neuroprotective effect of IGF-1 in vivo, in a rat model of Huntingtonʼs disease using the NMDA receptor agonist quinolinate. Continuous intracerebroventricular infusion of recombinant IGF-1 (0.25 μg/h for 2 days) in the rat brain, produced a significant 8-fold increase in striatal levels of the growth factor. Histological evaluation after intrastriatal injection of quinolinate showed that IGF-1 treatment significantly attenuated striatal degeneration. These results further support the therapeutic interest of IGF-1 in Huntingtonʼs disease.
ISSN:	0959-4965 1473-558X
DOI:	10.1097/00001756-200410050-00022