Inductive Coupling and Flow for Increased NMR Sensitivity

Inductive Coupling and Flow for Increased NMR Sensitivity

A device is proposed to enhance the NMR sensitivity of slowly relaxing nuclei, taking advantage of a controlled solution flow within a microfluidic circuit and microsized NMR detection. Unlike our previous work (Carret et al. Anal. Chem. 2017, 89 (5), 2995−3000 ), this setup can be easily installed...

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Veröffentlicht in:Analytical chemistry (Washington) 2018-10, Vol.90 (19), p.11169-11173
Hauptverfasser: Carret, Guillaume, Berthelot, Thomas, Berthault, Patrick
Format: Artikel
Sprache:eng
Schlagworte:
Analytical chemistry
Chemical Sciences
Chemistry
Inductive coupling
Material chemistry
Microfluidics
NMR
Nuclear magnetic resonance
Nuclei
Sensitivity
Sensitivity analysis
Sensitivity enhancement
Studies
Time
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Beschreibung
Zusammenfassung:A device is proposed to enhance the NMR sensitivity of slowly relaxing nuclei, taking advantage of a controlled solution flow within a microfluidic circuit and microsized NMR detection. Unlike our previous work (Carret et al. Anal. Chem. 2017, 89 (5), 2995−3000 ), this setup can be easily installed on any commercial NMR probehead as it uses induction between the commercial antenna and the microcoil. Such a system leads to a significant gain in sensitivity per time unit for slowly relaxing nuclei while preserving the capabilities of the host probehead.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.8b01775