Rethinking protein drug design with highly accurate structure prediction of anti-CRISPR proteins

Protein therapeutics play an important role in controlling the functions and activities of disease-causing proteins in modern medicine. Despite protein therapeutics having several advantages over traditional small-molecule therapeutics, further development has been hindered by drug complexity and de...

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Hauptverfasser:	Park, Homin, Park, Yunseol, Vankerschaver, Joris, Van Messem, Arnout, De Neve, Wesley, Shim, Hyunjin
Format:	Artikel
Sprache:	eng
Schlagworte:	AlphaFold anti-CRISPR proteins bacteriophages Biology and Life Sciences CAS SYSTEMS Drug Discovery GENES in-silico drug design Mathematics and Statistics Molecular Medicine Pharmaceutical Science prokaryotic defence mechanisms protein drug REPEATS RNA SEQUENCE structural biology Technology and Engineering TREE VIRUSES
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