Circadian rhythm of water diuresis and salt excretion in treatment naïve children with nocturnal polyuria and the influence on desmopressin response

Nocturnal enuresis is caused by a mismatch between nocturnal diuresis and functional bladder volume. Nocturnal polyuria (nocturnal diuresis > 130% of the expected bladder capacity for age, by ICCS definition) is a known pathophysiological mechanism of bedwetting. Other comorbidities such as constipation, mental health problems, and sleep disorders may play a role in prognosis and/or therapy response. In the prospective study (B670201212) we investigated the correlation of different sleep parameters and neuropsychological findings with specific enuresis characteristics and response to desmopressin treatment in children with nocturnal polyuria. The children participating in this study underwent polysomnography and had a 24-hour urine concentration profile before and 6 months after starting desmopressin. The primary research questions have since been published. Recently, there are indications that, but by analogy with nocturia in adults, not only water diuresis but also disturbed circadian rhythm of osmotic excretion play a role, but especially in treatment-resistant enuresis: The existing database offers the possibility to assess the importance of these factors. evaluate without having to re-study patients Our aim is to perform a post-hoc analysis on the existing anonymized database of the above study, in which we wish to analyze data (urine volumes, electrolytes, osmolarity, creatinine), to determine the renal circadian rhythm of water diuresis and salt and osmotic excretion analyze. In addition, the correlation with nocturnal polyuria and desmopressin response will also be investigated.