Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Willems, Sara M, Wright, Daniel J, Day, Felix R, Joshi, Peter K, Matteini, Amy M, Garton, Fleur C, Oskolkov, Nikolay, Mangino, Massimo, Lek, Monkol, Wang, Guan, Oldmeadow, Christopher, Gaulton, Kyle J, Miyamoto-Mikami, Eri, Rivas, Manuel A, Loh, Po-Ru, Aadahl, Mette, Amin, Najaf, Benyamin, Beben, Cheng, Yu-Ching, Cięszczyk, Paweł, Eriksson, Karl-Fredrik, Eynon, Nir, Linneberg, Allan, Mitchell, Braxton D, Miyachi, Motohiko, Murakami, Haruka, Padmanabhan, Sandosh, Pandey, Ashutosh, Papadimitriou, Ioannis, Rajpal, Deepak K, Sale, Craig, Schnurr, Theresia M, Sessa, Francesco, Tobin, Martin D, Varley, Ian, Wray, Naomi R, MacArthur, Daniel G, Waterworth, Dawn M, Oei, Ling, Zheng, Hou-Feng, Forgetta, Vincenzo, Leong, Aaron, Mokry, Lauren E, Ross, Stephanie, Bowden, Jack, Warrington, Nicole M, Murray, Anna, Tsilidis, Konstantinos K, Medina-Gómez, Carolina, Bis, Joshua C, Chasman, Daniel I, Demissie, Serkalem, Hsu, Yi-Hsiang, Ingvarsson, Thorvaldur, Kähönen, Mika, Kammerer, Candace, Lacroix, Andrea Z, Li, Guo, Liu, Ching-Ti, Liu, Yongmei, Mägi, Reedik, Nielson, Carrie M, Siggeirsdotir, Kristin, Sigurdsson, Gunnar, Stefansson, Kari, Trompet, Stella, Vandenput, Liesbeth, Xiao, Su-Mei, Evans, Daniel S, Cauley, Jane, de Groot, Lisette CPGM, Esko, Tonu, Harris, Tamara B, Ikram, Arfan MA, Kaptoge, Stephen, Kung, Annie Wai Chee, Lehtimäki, Terho, Metspalu, Andres, Orwoll, Erick, Psaty, Bruce M, Raitakari, Olli T, Ralston, Stuart W, Ridker, Paul M, Robbins, John A, Styrkarsdottir, Unnur, Thorstensdottir, Unnur, Uitterlinden, Andre G, Zmuda, Joseph, Evangelou, Evangelos, Evans, David M, Fuku, Noriyuki, Franks, Paul W, van Duijn, Cornelia M, Hansen, Torben, Hansson, Ola, Spector, Tim, Murabito, Joanne M, Langenberg, Claudia, Wareham, Nick J, Scott, Robert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences DISEASE Exercise Physiology and nutrition FRACTURES GENETIC INFLUENCES GENOME-WIDE ASSOCIATION GROWTH-FACTOR-ALPHA INSTRUMENTS Medicine and Health Sciences MENDELIAN RANDOMIZATION METAANALYSIS SKELETAL-MUSCLE VARIANTS
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P
ISSN:	2041-1723 2041-1723