Aviremia 10 years postdiscontinuation of antiretroviral therapy initiated during primary human immunodeficiency virus-1 infection and association with gag-specific T-cell responses

Combination antiretroviral therapy during primary human immunodeficiency virus-1 infection may enable long-term drug-free virological control in rare individuals. We describe a female who maintained aviremia and a normal CD4(+)/CD8(+) T cell ratio for 10 years after stopping therapy, despite a persi...

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Hauptverfasser:	Kinloch-de Loes, Sabine, Dorell, Lucy, Yang, Hongbing, Hardy, Gareth AD, Yerly, Sabine, Cellerai, Cristina, Vandekerckhove, Linos, De Spiegelaere, Ward, Malatinková, Eva, Koh, Willie Wee Lee, Johnson, Margaret A
Format:	Artikel
Sprache:	eng
Schlagworte:	antiretroviral therapy BLOOD CD8 T cell DIAGNOSIS DNA HIV-1 INFECTION HIV-1 reservoir LOAD Medicine and Health Sciences PCR primary HIV-1 infection QUANTIFICATION viral inhibition assay
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Zusammenfassung:	Combination antiretroviral therapy during primary human immunodeficiency virus-1 infection may enable long-term drug-free virological control in rare individuals. We describe a female who maintained aviremia and a normal CD4(+)/CD8(+) T cell ratio for 10 years after stopping therapy, despite a persistent viral reservoir. Cellular immune responses may have contributed to this outcome.
ISSN:	2328-8957 2328-8957