Natural TCRs targeting [KRAS.sup.G12V] display fine specificity and sensitivity to human solid tumors

Natural TCRs targeting [KRAS.sup.G12V] display fine specificity and sensitivity to human solid tumors

TRIAL REGISTRATION. ClinicalTrials.gov NCT03592888.

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Bibliographische Detailangaben
Veröffentlicht in:The Journal of clinical investigation 2024-11, Vol.134 (21)
Hauptverfasser: Bear, Adham S, Nadler, Rebecca B, O'Hara, Mark H, Stanton, Kelsey L, Xu, Chong, Saporito, Robert J, Rech, Andrew J, Baroja, Miren L, Blanchard, Tatiana, Elliott, Maxwell H, Ford, Michael J, Jones, Richard, Patel, Shivang, Brennan, Andrea, O'Neil, Zachary, Powell, Daniel J., Jr, Vonderheide, Robert H, Linette, Gerald P, Carreno, Beatriz M
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Antigen receptors, T cell
Antigenic determinants
Cancer
Cancer vaccines
Cellular therapy
Gene mutations
Health aspects
Histocompatibility antigens
HLA histocompatibility antigens
Oncogenes
Oncology, Experimental
Peptides
Receptors
T cells
Vaccination
Vaccines
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Zusammenfassung:TRIAL REGISTRATION. ClinicalTrials.gov NCT03592888.
ISSN:0021-9738
DOI:10.1172/JCI175790