SPECTROSCOPIC AND BIOLOGICAL STUDIES OF Pd-1,3,4-OXADIAZOLE-2-THIOL

Reactions of [Na.sub.2][PdCl.sub.4] with two equivalents of 5-(p-tolyl)-1,3,4-oxadiazole-2-thiol (MoxSH), afford complex of the type [Pd(MoxS)2] (1). Further reaction with equivalent mole of diphosphine ligand {[Ph.sub.2]P[(C[H.sub.2]).sub.n][PPh.sub.2]} ( where n = 1 dppm, 2 dppe, 3 dppp, 4 dppb, [(C[H.sub.2]).sub.n] = dppf ) or two equivalents of triphenyl phosphine or triphenyl phosphine sulfide affords mixed-ligand complexes of the type [Pd[(MoxS).sub.2]([Ph.sub.2]P[(C[H.sub.2]).sub.n][PPh.sub.2])] (2-6), [Pd[(MoxS).sub.2][([PPh.sub.3]).sub.2]] (7) and [Pd[(MoxS).sub.2][([SPPh.sub.3]).sub.2]](8). The prepared complexes were characterized using different physical and spectroscopic methods. The results indicated that the MoxS ligand behave as coordinate in a anion monodentate fashion sulfur atom to give a square planer around the metal ion. Preliminary anti-bacterial activity has been assessed against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis bacteria. The prepared complexes show good activity in compared with standard drug. [Pd(MoxS)2(dppf)] (6) displays good activity (18, 22 and 20 mm) against certain tested microbes Escherichia coli, Staphylococcus aureus and Bacillus subtilis, respectively. KEY WORDS: Complexes, Palladium, Thione, Anti-bacteria, Phosphine