Quantitative analysis of the impact of seasonal cyclicality on serum 25-hydroxycholecalciferol concentration in Northwest Arctic

Background: 25-hydroxycholecalciferol also known as 25-hydroxyvitamin D plays a vital role in numerous physiological functions within the human body, and its deficiency is associated with conditions such as osteoporosis, cardiovascular diseases, autoimmune disorders, and certain cancers. In Alaska, sunlight exposure is a critical factor that influences vitamin D levels in the population. Methods: This study involved a review of serum 25-hydroxyvitamin D [25(OH)D] levels from January 2014 to June 2018 for Alaska residents, including individuals aged 18 years or older who were permanent residents of the area. The exclusion criteria comprised acute or chronic liver or kidney dysfunction, anemia, cancer history, absorption deficiency, and vitamin D supplementation exceeding 500 IU/day within 90 days before the blood draw. Results: A total of 304 participants, including 107 males (35.2%) and 197 females (64.8%), with a mean age of 50.88, were included. The overall mean serum level of 25(OH)D was 22.7 ± 9.89 ng/mL. Females exhibited a higher mean level (23.40 ± 10.24 ng/mL) than males (21.03 ± 9.05 ng/mL) ( P