Evaluation of the relationship between serum irisin levels and disease activity in ankylosing spondylitis patients/Ankilozan spondilit hastalarinda serum irisin duzeyi ile hastalik aktivitesi arasindaki iliskinin degerlendirilmesi

Objective: Axial spondyloarthrltls Is a chronic Inflammatory disease primarily affecting the axial skeleton and the sacroiliac joints. In this study, we aimed to assess irisin levels in patients with ankylosing spondylitis (AS), compare them with healthy individuals, and explore the relationship between this adipomiyokine and activity, function, and structural damage in AS. Methods: Ninety-seven patients classified as AS according to the modified New York criteria and 48 healthy controls were consecutively enrolled in the study. Serum irisin, interleukin (IL) 6, and high- sensitivity C-reactive protein (hs-CRP) measurements were performed using the ELISA method. Disease activity, functional assessments, and spinal radiographic scoring were conducted. The relationship between laboratory parameters, disease activation, and radiological parameters was evaluated using the Spearman correlation test. Results: The age and gender distributions of AS and controls were found to be similar. Smoking was significantly higher in the AS group (p=0.004). No significant difference in serum irisin levels was observed between AS and controls [100.0 (65.9) versus 103.0 (45.5), p=0.997]. However, serum IL-6, hs-CRP, and erythrocyte sedimentation rate averages were significantly higher in the patient group. There was no significant correlation between serum irisin levels in the AS group and inflammatory markers, Bath Ankylosing Spondylitis Functional index, Bath Ankylosing Spondylitis Disease Activity index, and Ankylosing Spondylitis Disease Activity score CRP scores, while a low to moderate correlation was found with the mSASS score (r: 0.362, p=0.005). Conclusion: In this study, we did not find a significant difference in serum irisin levels between healthy controls and AS patients, nor did we observe a significant connection between irisin levels and disease activity. Keywords: Ankylosing spondylitis, irisin, myokine Amac: Aksiyal spondiloartrit baslica aksiyal iskeleti ve sakroiliyak eklemleri tutan kronik enflamatuvar bir hastaliktir. Bu calismada, ankilozan spondilitli (AS) hastalarda irisin duzeyini degerlendirmek, saglikli bireylerle karsilastirmak ve bu adipomiyokin ile AS arasindaki aktivite, fonksiyon ve yapisal hasar arasindaki iliskiyi test etmeyi amacladik. Yontem: Modifiye New York kriterlerine gore AS olarak siniflandirilan 97 hasta ve 48 saglikli kontrol calismaya ardisik olarak dahil edildi. ELISA yontemiyle serum irisin, interlokin (IL) 6, yuksek duyarlikli