Matrix metalloproteinase-1 and microRNA-486-5p in urinary exosomes can be used to detect early lung cancer: A preliminary report

Matrix metalloproteinase-1 and microRNA-486-5p in urinary exosomes can be used to detect early lung cancer: A preliminary report

The present study describes a novel molecular-genetic method suitable for lung cancer (LC) screening in the work-place and at community health centers. Using urinary-isolated exosomes from 35 patients with LC and 40 healthy volunteers, the expression ratio of MMP 1/CD63, and the relative expres sion...

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Veröffentlicht in:Oncology letters 2024-03, Vol.27 (3), p.1
Hauptverfasser: Ando, Wataru, Sogabe, Masaya, Ishikawa, Shigemi, Uematsu, Takayuki, Furuya, Hiroyuki, Yokomori, Hiroaki, Kohgo, Yutaka, Otori, Katsuya, Nakano, Tomoyuki, Endo, Shunsuke, Tsubochi, Hiroyoshi, Okazaki, Isao
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Cancer
Community health services
Diagnosis
Genetic aspects
Health aspects
Lung cancer
MicroRNA
Oncology, Experimental
Women
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Zusammenfassung:The present study describes a novel molecular-genetic method suitable for lung cancer (LC) screening in the work-place and at community health centers. Using urinary-isolated exosomes from 35 patients with LC and 40 healthy volunteers, the expression ratio of MMP 1/CD63, and the relative expres sion levels of both microRNA (miRNA)-21 and miRNA-486-5p were measured, MMP-1/CD63 expression ratio was significantly higher in patients with LC than in the healthy controls {1.342 [95% confidence interval (CI): 0.890-1.974] vs. 0.600 (0.490-0.900); P
ISSN:1792-1074
DOI:10.3892/01.2024.14261