Antimigraine Effects of Awei Wu Wei Pills, A Monk’s Medicine

The Mongolian medicine (Awei Wu Wei pills) was evaluated as a potential treatment for Hirschsprung's migraine in a Sprague-Dawley rat model. The results of this study showed a dose-dependent decrease in the duration of ear redness and head scratching, two behavioral attributes of migraine. The mechanism involves inhibition of the c-Jun N-terminal kinase signaling pathway, leading to decreased calcitonin gene-related peptide and nitric oxide expression and reducing vasodilation, serotonin, dopamine, and beta-endorphin concentrations following administration of Awei Wu Wei pills. In conclusion, Awei Wu Wei pills demonstrate promising antimigraine effects. Keywords: Awei Wu Wei pills, CGRP, JNK, Migraine, Neurotransmitters Abbreviations Used: Awei Wu Wei pills, AWW pills; Beta-Endorphin, p-EP; Calcitonin gene-related peptide, CGRP; Central nervous system, CNS; Cytochrome P450 enzyme, CYP450; Dopamine, DA; Integrated optical density, IOD; Isotonic saline, IS; c-Jun N-terminal kinase, JNK; Nitric oxide, NO; Non-steroidal anti-inflammatory drugs, NSAIDs; Paw twitch latency, PWL; Serotonin, 5-HT; Trigeminovascular system., TGVS; Yangxue Qingnao granule, YQG Corresponding Author: Dr. Gaowa Wuyun, No. 1742, Huolinhe Street, Keerqin District, Tongliao City, Inner Mongolia, China; Email: wuyungaowa2017@163.com