Adaptive evolution of Methylotuvimicrobium alcaliphilum to grow in the presence of rhamnolipids improves fatty acid and rhamnolipid production from [CH.sub.4]

Adaptive evolution of Methylotuvimicrobium alcaliphilum to grow in the presence of rhamnolipids improves fatty acid and rhamnolipid production from [CH.sub.4]

Rhamnolipids (RLs) are well-studied biosurfactants naturally produced by pathogenic strains of Pseudomonas aeruginosa. Current methods to produce RLs in native and heterologous hosts have focused on carbohydrates as production substrate; however, methane ([CH.sub.4]) provides an intriguing alternati...

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Veröffentlicht in:Journal of industrial microbiology & biotechnology 2022-03, Vol.49 (2), p.1
Hauptverfasser: Awasthi, Deepika, Tang, Yung-Hsu, Amer, Bashar, Baidoo, Edward E.K, Gin, Jennifer, Chen, Yan, Petzold, Christopher J, Kalyuzhnaya, Marina, Singer, Steven W
Format: Artikel
Sprache:eng
Schlagworte:
Air pollution
Analysis
Biological products
Cell death
Fatty acids
Greenhouse gases
Methane
Natural gas
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Zusammenfassung:Rhamnolipids (RLs) are well-studied biosurfactants naturally produced by pathogenic strains of Pseudomonas aeruginosa. Current methods to produce RLs in native and heterologous hosts have focused on carbohydrates as production substrate; however, methane ([CH.sub.4]) provides an intriguing alternative as a substrate for RL production because it is low cost and may mitigate greenhouse gas emissions. Here, we demonstrate RL production from [CH.sub.4] by Methylotuuimicrobium alcaliphilum DSM19304. RLs are inhibitory to M. alcaliphilum growth (
ISSN:1367-5435
DOI:10.1093/jimb/kuac002