Therapeutic Efficacy of Bovine Basic Fibroblast Growth Factor Combined with Ultrapulsed Fractional C[O.sub.2] Laser in Acne Scars: Randomized Controlled Trial

Objective: To observe the therapeutic efficacy of ultrapulsed fractional C[O.sub.2] laser combined with bovine basic fibroblast growth factor (bFGF) on acne scars, so as to provide clinical evidence for future treatment of acne scars. Methods: One hundred and twenty patients with acne scars admitted between October 2021 and August 2022 were selected as the research participants, of which 60 cases treated with bFGF plus ultrapulsed fractional C[O.sub.2] laser were regarded as the research group (RG) and 60 cases with ultrapulsed fractional C[O.sub.2] laser therapy alone were set as the control group (CG). The clinical efficacy, Echelle devaluation clinique des cicatrices d'acne (ECCA) score, and scar base depth before and after treatment were comparatively analyzed, and changes in skin pore value, texture value and skin barrier function were detected. Finally, the duration of redness, scabbing and erythema after treatment and the incidence of adverse reactions after treatment were counted. Results: A higher overall response rate was determined in RG versus CG (P