THE USE OF TRANEXAMIC ACID IN DERMATOLOGY/PRIMJENA TRANEKSAMICNE KISELINE U DERMATOLOGIJI

Tranexamic acid is a synthetic derivative of the amino acid lysine, an antifibrinolytic that is primarily used to reduce bleeding in surgery, trauma, and dental procedures. Its anti-inflammatory and anti-angiogenic properties, as well as its ability to suppress melanogenesis have enabled it to be used in dermatology in the treatment of skin conditions such as melasma, acne, post-inflammatory hyperpigmentation, rosacea and angioedema. Tranexamic acid can be used by various routes of administration including oral, topical and intradermal injection, and in combination with other treatment methods. This review article presents evidence for the effectiveness of tranexamic acid in the treatment of various skin disorders. Key words: Tranexamic acid; Dermatology; Melasma; Acne; Rosacea; Angioedema Traneksamicna kiselina sintetski je derivat aminokiseline lizina, antifibrinolitika koji se prvenstveno rabi za smanjenje krvarenja u kirurskim zahvatima, traumi i stomatoloskim zahvatima. Njegova protuupalna i antiangiogena svojstva, kao i njegova sposobnost suzbijanja melanogeneze omogucili su mu upotrebu u dermatologiji u lijecenju koznih stanja kao sto su melazma, akne, poslijeupalna hiperpigmentacija, rozacea i angioedem. Traneksamicnu kiselinu moguce je primijeniti na razlicite nacine: oralno, lokalno i intradermalno te u kombinaciji s drugim metodama lijecenja. Ovaj pregledni clanak prikazuje dokaze o ucinkovitosti traneksamicne kiseline u lijecenju razlicitih koznih poremecaja. Kljucne rijeci: Traneksamicna kiselina; Dermatologija; Melazma; Akne; Rozacea; Angioedem