Investigation of Clinical Histopathologic Features and Metabolic Parameters of [.sup.18F]-FDG PET/CT in Invasive Breast Carcinoma with a Micropapillary Component/Mikropapiller Komponentli Invazif Meme Kanserinde Klinik, Histopatolojik Ozellikler ile [.sup.18F]-FDG PET/BT Metabolik Parametrelerin Incelenmesi

Objectives: The aim of this study was to evaluate the correlation between clinical histopathologic features and micropapillary (MP) ratio with the maximum standardized uptake value (SU[V.sub.max]) derived from [.sup.18F]-fluorodeoxyglucose positron emission tomography/computed tomography ([.sup.18F]-FDG PET/CT) in treatment naive breast cancer. Methods: Twenty-nine patients diagnosed with breast cancer with a MP component who underwent PET/CT imaging before any local and/or systemic treatment were included in this retrospective study. All clinical histopathological features were recorded. SU[V.sub.max] values were measured from [.sup.18F]-FDG PET images for primary tumors and metastatic axillary lymph nodes. Results: MP component percentage did not correlate with any clinical histopathological features except age. At early ages, the MP component ratio was significantly higher. Our results showed that there is no significant correlation between the SU[V.sub.max] value and MP component percentage. Conclusion: A high SU[V.sub.max] value is generally expected in aggressive malignancies. However, this assumption may not be valid for the MP subgroup, which has an aggressive course compared to other subgroups in breast cancer. Keywords: [.sup.18F]-FDG, micropapillary, breast cancer, PET/CT, SU[V.sub.max] Amac: Bu calismanin amaci, tedavi uygulanmamis meme kanserinde klinik, histopatolojik ozellikler, mikropapiller (MP) komponent orani ile [.sup.18F]-florodeoksiglukoz pozitron emisyon tomografisi/bilgisayarli tomografiden ([.sup.18F]-FDG PET/BT) elde edilen maksimum standardize tutulum degeri (SUV k ) arasindaki iliskiyi degerlendirmektir. Yontem: Bu retrospektif calismaya herhangi bir lokal ve/veya sistemik tedavi uygulanmadan once PET/BT goruntulemesi yapilan MP komponentli meme kanseri tanili 29 hasta dahil edildi. Tum klinik, histopatolojik ozellikler kaydedildi. Primer tumorlerin ve metastatik aksiller lenf nodlarinin SU[V.sub.mals] k degerleri [.sup.18F]-FDG PET goruntulerinden olculdu. Bulgular: MP komponent orani yas disinda herhangi bir klinik-histopatolojik ozellik ile korele degildi. Erken yaslarda, MP komponent orani anlamli olarak daha yuksekti. Sonuclarimiz SU[V.sub.mals] k degeri ile MP komponent orani arasinda anlamli bir iliski olmadigini gosterdi. Sonuc: Agresif malignitelerde genelde yuksek duzeyde SU[V.sub.mals] k degeri beklenir. Ancak bu varsayim meme kanserinde diger alt gruplara kiyasla agresif seyir gosteren MP alt grup icin gecerli olmaya