Examining Risks of Reversible Clomiphene-Associated Manic Episodes to Patients

We recently managed a case of clomiphene (Clomid)-induced acute mania that was resolved following empiric treatment with olanzapine and discontinuation of clomiphene. Based on our experience with this case, we advise physicians to consider clomiphene-associated phenomena with acute psychiatric presentations shortly after use of clomiphene. Discontinuing clomiphene, engaging in close serial clinical observation of mental status, empirically managing psychiatric symptoms, subsequently avoiding clomiphene, and following up clinically are indicated.