Do Plasma Nitric Oxide Levels Have an Impact on Unprovoked Migraine Attacks?/Plazma Nitrik Oksit Duzeylerinin Provoke Edilmemis Migren Ataklarinda Etkisi Var mi?

Objective: Provocation studies on the role of nitric oxide (NO) in the pathophysiology of migraine have long been conducted and provide important information. Although there are many provocation studies in the literature, there are fewer publications on the role of NO in spontaneous migraine attacks. In this study, we aimed to compare the serum NO levels during unprovoked attacks in patients with migraine using the values in the interictal period and the results of the control group. Materials and Methods: Thirty migraine patients were evaluated for plasma NO levels during the natural course of unprovoked attacks and in the interictal period. They were also compared with the results of 25 healthy controls. Results: The mean plasma NO levels were 20.99 [+ or -] 4.93 [micro]mol/l during migraine attacks, 25.97 [+ or -] 9.83 [micro]mol/l between attacks and 23.22 [+ or -] 7.57 [micro]mol/l in the control group. According to these results, the mean plasma NO levels were significantly lower in migraineurs during attacks compared to the non-attack period (P = 0.025), but there was no significant difference with controls (P = 0.212 and P = 0.247, respectively). Conclusion: To evaluate whether NO has an effect on the natural history of migraine attacks, more spontaneous attack studies involving methods other than measuring serum levels are needed. Keywords: Migraine, nitric oxide, spontaneous attack Amac: Migren patofizyolojisinde nitrik oksitin (NO) rolu ile ilgili provokasyon calismalari uzun zamandir yapilmakta ve onemli bilgiler vermektedir. Literaturde cok sayida provokasyon calismasi olmasina ragmen spontan migren ataklarinda NO'nun rolu ile ilgili daha az sayida yayin mevcuttur. Bu calismada migren hastalarinda provoke edilmemis ataklar sirasindaki serum NO degerleri ile interiktal donemdeki degerler ve kontrol grubunun sonuclarinin karsilastirilmasi amaclanmistir. Gerec ve Yontem: Otuz migrenli hastanin provoke edilmemis ataklarinin dogal seyrinde ve ataksiz donemlerinde plazma NO duzeylerini degerlendirildi. Ayrica bunlar 25 saglikli kontrolun sonuclariyla karsilastirildi. Bulgular: Ortalama plazma NO seviyeleri migren ataklari sirasinda 20,99 [+ or -] 4,93 [micro]mol/l, ataklar arasinda 25,97 [+ or -] 9,83 [micro]mol/l ve kontrol grubunda 23,22 [+ or -] 7,57 [micro]mol/l idi. Bu sonuclara gore migrenlilerde ataklar sirasinda ortalama plazma NO duzeyleri ataksiz doneme gore anlamli olarak daha dusuktu (P = 0,025), ancak kontrollerle anlamli bir fark yoktu