Effects of Tenecteplase on vascular recanalization, clinical prognosis and safety evaluation in patients with acute ischemic stroke: a systematic review and meta-analysis

Objective: To assess the effect and safety of Tenecteplase (TNK) on vascular recanalization, clinical prognosis, and safety in patients with acute ischemic stroke (AIS). Methods: PubMed, EMBASE, ScienceDirect, Cochrane Library, China National Knowledge Infrastructure (CNKI), China VIP Database, Wanfang Database and China Biomedical Literature Database (CBM) online database were searched for casecontrol trials in patients with AIS treated with TNK and alteplase. Between January 2010 and the present, the search period was limited. The data were collected separately by two researchers, and a meta-analysis of the collected data was conducted by RevMan5.3 statistical software using the Cochrane Handbook 5.3 standard for assessing bias risk. Results: Finally, 5 clinical control studies were contained. The total number of samples collected was 1569. In order to determine the improvement rate of early neurological function following treatment, an analysis of meta-analyses was conducted. Based on the fixed effect model analysis, the study group showed a noticeable improvement in early neurological function (P0.05). To determine the incidence of bleeding, an analysis of meta-analyses was conducted. In effect model analysis, bleeding incidence after treatment was not noticeably different from baseline (P>0.05). To determine the mortality rate, an analysis of meta-analyses was conducted. No statistical difference was found in the mortality rate after treatment (P>0.05). Some of the distributions were asymmetric, suggesting that in the contained literature, a certain publication bias was present, which could be expla