A clinical analysis of shape and function of diaphragm in patients with sepsis assessed by para-ultrasound based on data analysis

Objective: To investigate evaluation value of septal muscle contraction velocity and displacement time index measured by ultrasound in sepsis patients. Methods: 59 patients with sepsis admitted to our hospital from September 2015 to January 2021 were recruited as research objects; According to principle of age sex 1:1 ratio matching, 59 healthy volunteers were randomly recruited for outpatient physical examination in same period as control. All subjects completed bedside ultrasonic testing within 24 hours after treatment, and collected ultrasonic data under calm breathing and deep breathing conditions respectively: (1) Displacement of septal muscle; (2) Inspiratory time; (3) The contraction speed of septum is equal to displacement/inspiratory time of septum, and internal contractility of septum is evaluated; (4) Displacement time index, which is equal to diaphragm displacement X inspiratory time, is used to indirectly evaluate diaphragm work. SPSS software was used to analyze general baseline data and ultrasonic testing related data. Results: (1) Comparison of general baseline data: There was no difference in body mass index, mean arterial pressure and underlying diseases(all P>0.05); (2) Comparison of septum ultrasonic data: (septum displacement: septum displacement in sepsis was lower under calm breathing and deep breathing conditions; [C] Inspiratory time: The inspiratory time in sepsis was shorter under calm breathing and deep breathing conditions; @ Contraction speed: In deep breathing state, contraction speed of septum in sepsis was lower, indicating that contraction capacity of septum was reduced; @ Displacement time index: displacement time index of septum in sepsis was lower under conditions of calm breathing and deep breathing, indicating that work of septum was reduced. Conclusion: In early stage of sepsis, sepsis patients have shown a decrease in contraction velocity and displacement time index of diaphragm deep breathing under ultrasound, indicating that internal contraction ability of diaphragm and work of diaphragm have decreased in early stage of sepsis. Bedside ultrasound can effectively evaluate septal muscle contraction function of sepsis patients. Keywords: diaphragmatic function, sepsis, ultrasound, systolic velocity, displacement time index