1-Aryl-4--benzodiazepines: synthesis and thiophene ring annulation to 1,2-diazepine core

1-Aryl-4--benzodiazepines: synthesis and thiophene ring annulation to 1,2-diazepine core

1-Aryl-2-[(1-aryl-5H-2,3-benzodiazepin-4-yl)sulfanyl]ethanones were obtained by the alkylation of 1-aryl-2,3-benzodiazepine-4(3H,5H)-thiones with 1-aryl-2-bromoethanones. A reaction for the annulation of the thiophene core to the 1,2-diazepine ring as a result of intramolecular cyclization involving...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2023-07, Vol.59 (6-7), p.508
Hauptverfasser: Bohdan, Natalia M, Stepanova, Diana S, Suikov, Serhii Yu, Popov, Vadim Yu, Ishkov, Yuri V, Bohza, Serhii L
Format: Artikel
Sprache:eng
Schlagworte:
Antianxiety agents
Benzodiazepines
Thiophene
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Zusammenfassung:1-Aryl-2-[(1-aryl-5H-2,3-benzodiazepin-4-yl)sulfanyl]ethanones were obtained by the alkylation of 1-aryl-2,3-benzodiazepine-4(3H,5H)-thiones with 1-aryl-2-bromoethanones. A reaction for the annulation of the thiophene core to the 1,2-diazepine ring as a result of intramolecular cyclization involving a 4-aroylmethylsulfanyl substituent and C(4)-C(5) bond of diazepine was developed. Derivatives of a new thieno[2,3-d][2,3]benzodiazepine heterocyclic system were synthesized.
ISSN:0009-3122
DOI:10.1007/s10593-023-03223-w