Peripheral blood lymphocyte subset count in COVID-19 patients

Peripheral blood lymphocyte subset count in COVID-19 patients

Background: (COVID-19) pathophysiology and the predictive factors are not fully understood, but lymphocyte dysregulation appears to play a role. Aim and Objectives: To explore the clinical value of lymphocyte subset changes in COVID-19 patients' peripheral blood, which may illustrate the pathog...

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Veröffentlicht in:The Egyptian journal of haematology : the official journal of the Egyptian Society of Haematology 2023-01, Vol.48 (1), p.28-36
Hauptverfasser: Shahin, Doaa, Mortada, Metwaly, Abousamra, Nashwa, El Menshawy, Nadia, Hasan, Ahmed, Eisa, Noha, EL-Ashwah, Shaimaa, Emarah, Ziad, Elmaria, Marwa, Bakeer, Mostafa, Saleh, Ahmed, Ghannam, Mayada
Format: Artikel
Sprache:eng
Schlagworte:
Ethylenediaminetetraacetic acid
Hospital patients
Lymphocytes
Medical research
Medicine, Experimental
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Zusammenfassung:Background: (COVID-19) pathophysiology and the predictive factors are not fully understood, but lymphocyte dysregulation appears to play a role. Aim and Objectives: To explore the clinical value of lymphocyte subset changes in COVID-19 patients' peripheral blood, which may illustrate the pathogenesis of COVID-19. Methods: This is prospective cohort study of 73 hospitalized patients with confirmed COVID-19 who were classified into two groups: non-severe and severe. Lymphocyte subsets (CD3, CD4, CD8, CD19, and CD56) were assessed using flow cytometry. Results Lymphocyte gate, CD3, CD4, CD8, and CD56 counts were significantly reduced in severe cases compared with nonsevere cases (P0.001, 0.006, 0.016, 0.011, and 0.008 respectively). Patients were divided into two groups according to cut off age (
ISSN:1110-1067
2090-9268
DOI:10.4103/ejh.ejh_3_22