Synthesis of Pseudooligosaccharides Related to the Capsular Phosphoglycan of IHaemophilus influenzae/I Type Ia/I

Synthesis of spacer-armed pseudodi-, pseudotetra-, and pseudohexasaccharides related to the capsular phosphoglycan of Haemophilus influenzae type a, the second most virulent serotype of H. influenzae (after type b), was performed for the first time via iterative chain elongation using H-phosphonate...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2023-07, Vol.28 (15)
Hauptverfasser: Kamneva, Anastasia A, Yashunsky, Dmitry V, Khatuntseva, Elena A, Nifantiev, Nikolay E
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Sprache:eng
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Zusammenfassung:Synthesis of spacer-armed pseudodi-, pseudotetra-, and pseudohexasaccharides related to the capsular phosphoglycan of Haemophilus influenzae type a, the second most virulent serotype of H. influenzae (after type b), was performed for the first time via iterative chain elongation using H-phosphonate chemistry for the formation of inter-unit phosphodiester bridges. These compounds were prepared for the design of neoglycoconjugates, as exemplified by the transformation of the obtained pseudohexasaccharide derivative into a biotinylated glycoconjugate suitable for use in immunological studies, particularly in diagnostic screening systems as a coating antigen for streptavidin-coated plates and chip slides.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28155688