The Role of DHEA, NGF, and ADAMTS5 Pathways in Osteoarthritis and Current Developments/ Osteoartritte DHEA, NGF ve ADAMTS5 Yollarinin Rolu ve Mevcut Gelismeler

Degenerative joint disease is a condition that affects joints and is commonly referred to as osteoarthritis (OA). This form of arthritis is most prevalent among women and tends to become more frequent as people age. The pathogenesis of OA involves an imbalance of cytokines in favor of pro-inflammatory cytokines. However, the steroid hormone dehydroepiandrosterone (DHEA) exerts chondroprotective effects and regulates the balance of catabolic factors such as thrombospondin motif disintegrin and metalloproteinase (ADAMTS), thereby playing a role against OA. Pro-inflammatory cytokines induce aggrecanases, such as ADAMTS5, which degrade the extracellular matrix and contribute to OA. The molecule nerve growth factor (NGF), associated with pain in OA, is important for cartilage homeostasis, and DHEA can modulate pain by interfering with NGF receptors. This review covers the roles of DHEA, ADAMTS5, and NGF in the pathogenesis of OA, their relationship with pain pathways, and their use in current treatments. We also anticipate that these pathways will be crucial in developing new strategies to prevent and treat OA, and understanding their interactions may make it possible to enhanced the quality of life of patients with OA. Keywords: ADAMTS5, DHEA, NGF, osteoarthritis Dejeneratif eklem hastaligi, eklemleri etkileyen ve genellikle osteoartrit (OA) olarak adlandirilan bir durumdur. Bu artrit formu en cok kadinlar arasinda gorulur ve insanlar yaslandikca daha sik olma egilimindedir. OA'nin patogenezi, sitokinlerin pro-enflamatuvar sitokinler lehine dengesizligini icerir. Ancak steroid hormon dehidroepiandrosteron (DHEA) kondroprotektif etki gosterir ve trombospondin motif disintegrin ve metalloproteinaz (ADAMTS) gibi katabolik faktorlerin dengesini duzenleyerek OA'ya karsi rol oynar. Pro-enflamatuvar sitokinler, hucre disi matrisi bozan ve OA'ya katkida bulunan ADAMTS5 gibi agrekanazlari indukler. OA'da agri ile iliskili sinir buyume faktoru (NGF) molekulu, kikirdak homeostazi icin onemlidir ve DHEA, NGF reseptorlerine mudahale ederek agriyi module edebilir. Bu derlemede OA patogenezinde DHEA, ADAMTS5 ve NGF'nin rolleri, agri yolaklari ile iliskileri ve guncel tedavilerdeki kullanimlari ele alinmaktadir. Ayrica, bu yollarin OA'yi onlemek ve tedavi etmek icin yeni stratejiler gelistirmede cok onemli olacagini ve etkilesimlerinin anlasilmasinin OA'li hastalarin yasam kalitesini artirmayi mumkun kilacagini tahmin ediyoruz. Anahtar kelimeler: ADAMTS5, DHEA, NGF, osteoartr