Structure and Microbiological Activity of 1IH/I-benzo[Id/I]imidazole Derivatives

Three new crystal structures of 1H-benzo[d]imidazole derivatives were determined. In the structures of these compounds, an identical system of hydrogen bonds, C(4), was observed. Solid-state NMR was applied for testing the quality of the obtained samples. All of these compounds were tested for in vi...

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Veröffentlicht in:International journal of molecular sciences 2023-02, Vol.24 (4)
Hauptverfasser: Olczak, Andrzej, Pawlak, Tomasz, Kałużyńska, Sylwia, Gobis, Katarzyna, Korona-Głowniak, Izabela, Suśniak, Katarzyna, Zaborowski, Marcin, Szczesio, Małgorzata
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Sprache:eng
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Zusammenfassung:Three new crystal structures of 1H-benzo[d]imidazole derivatives were determined. In the structures of these compounds, an identical system of hydrogen bonds, C(4), was observed. Solid-state NMR was applied for testing the quality of the obtained samples. All of these compounds were tested for in vitro antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, as well as antifungal activity, by checking their selectivity. ADME calculations indicate that the compounds can be tested as potential drugs.
ISSN:1422-0067
DOI:10.3390/ijms24043319