A New Phenolic Glycoside with [alpha]-Glucosidase Inhibitory Activity from Viburnum cylindricum Leaves

A New Phenolic Glycoside with [alpha]-Glucosidase Inhibitory Activity from Viburnum cylindricum Leaves

One new phenolic glycoside (1) and two known stereoisomers (2 and 3) were isolated from the methanol extract of Viburnum cylindricum leaves. Their structures were determined as (7R,8S)-guaiacylglycerol 9-O-[beta]-D-glucopyranoside (1), (7S,8R)-guaiacylglycerol 9-O-[beta]-D-glucopyranoside (2), and (...

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Veröffentlicht in:Chemistry of natural compounds 2023-03, Vol.59 (2), p.275
Hauptverfasser: Zhang, Xiao-Hui, Chen, Jia, Tang, Yi-Yuan, Zhao, Zi-Yang, Shao, Jian-Hua, Zhao, Chun-Chao
Format: Artikel
Sprache:eng
Schlagworte:
Enzymes
Hydrolases
Medicine, Botanic
Medicine, Herbal
Type 2 diabetes
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Zusammenfassung:One new phenolic glycoside (1) and two known stereoisomers (2 and 3) were isolated from the methanol extract of Viburnum cylindricum leaves. Their structures were determined as (7R,8S)-guaiacylglycerol 9-O-[beta]-D-glucopyranoside (1), (7S,8R)-guaiacylglycerol 9-O-[beta]-D-glucopyranoside (2), and (7R,8R)-guaiacylglycerol 9-O-[beta]-D-glucopyranoside (3), respectively, by spectroscopic data (1D, 2D NMR, HR-ESI-MS, and ORD) and chemical methods. In addition, compound 1 showed potential [alpha]-glucosidase inhibitory activity with the IC.sub.50 value of 10.73 [mu]M in comparison with the positive control acarbose (IC.sub.50 = 18.84 [mu]M).
ISSN:0009-3130
DOI:10.1007/s10600-023-03975-z