Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in IStreptomyces/I sp. XS-16

Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in IStreptomyces/I sp. XS-16

Six angucyclines including three unreported compounds (1–3) were isolated from Streptomyces sp. XS-16 by overexpressing the native global regulator of SCrp (cyclic AMP receptor). The structures were characterized based on nuclear magnetic resonance (NMR) and spectrometry analysis and assisted by ele...

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Veröffentlicht in:Marine drugs 2023-04, Vol.21 (4)
Hauptverfasser: Xu, Xiao, Zhang, Falei, Zhou, Luning, Chang, Yimin, Che, Qian, Zhu, Tianjiao, Li, Dehai, Zhang, Guojian
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Chemical properties
Genetic aspects
Health aspects
Identification and classification
Metabolites
Pharmaceutical research
Streptomyces
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Zusammenfassung:Six angucyclines including three unreported compounds (1–3) were isolated from Streptomyces sp. XS-16 by overexpressing the native global regulator of SCrp (cyclic AMP receptor). The structures were characterized based on nuclear magnetic resonance (NMR) and spectrometry analysis and assisted by electronic circular dichroism (ECD) calculations. All compounds were tested for their antitumor and antimicrobial activities, and compound 1 showed different inhibitory activities against various tumor cell lines with IC[sub.50] values ranging from 0.32 to 5.33 μM.
ISSN:1660-3397
1660-3397
DOI:10.3390/md21040240