Electrochemical-Induced Cascade Reaction of 2-Formyl Benzonitrile with Anilines: Synthesis of IN/I-Aryl Isoindolinones

Electrochemical-Induced Cascade Reaction of 2-Formyl Benzonitrile with Anilines: Synthesis of IN/I-Aryl Isoindolinones

An electrochemical initiated tandem reaction of anilines with 2-formyl benzonitrile has been developed. Thus, unprecedented 3-N-aryl substituted isoindolinones have been conveniently achieved by constant current electrolysis in a divided cell using catalytic amount of electricity and supporting elec...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2022-11, Vol.27 (23)
Hauptverfasser: Morlacci, Valerio, Caruso, Tonino, Chiarini, Marco, Arcadi, Antonio, Aschi, Massimiliano, Palombi, Laura
Format: Artikel
Sprache:eng
Schlagworte:
Electrolysis
Nitriles
Tumor proteins
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Zusammenfassung:An electrochemical initiated tandem reaction of anilines with 2-formyl benzonitrile has been developed. Thus, unprecedented 3-N-aryl substituted isoindolinones have been conveniently achieved by constant current electrolysis in a divided cell using catalytic amount of electricity and supporting electrolyte and a Pt-cathode as working electrode. The origin of the electrochemical activation as well as the mechanism of the subsequent chemical cascade reactions have been investigated by DFT calculations.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27238199