Diethyl phosphonate
Bisphosphonates are widely used in medicine and related areas, mainly for the treatment of bone diseases, such as osteoporosis. However, their synthesis is usually performed under harsh reaction conditions. In order to overcome this limitation, the present work illustrates a new synthetic route to a...
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| Veröffentlicht in: | MolBank 2022-08, Vol.2022 (3) |
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| container_issue | 3 |
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| container_title | MolBank |
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| creator | López-Francés, Adrián Palacios, Francisco Maestro, Aitor Vicario, Javier |
| description | Bisphosphonates are widely used in medicine and related areas, mainly for the treatment of bone diseases, such as osteoporosis. However, their synthesis is usually performed under harsh reaction conditions. In order to overcome this limitation, the present work illustrates a new synthetic route to access the title α-aminobisphosphonate in milder reaction conditions using α-phosphorylated imines as key intermediates. |
| doi_str_mv | 10.3390/M1424 |
| format | Article |
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| identifier | ISSN: 1422-8599 |
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| language | eng |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Analysis Care and treatment Chemical synthesis Enzyme inhibitors Identification and classification Infrared spectroscopy Mass spectrometry Methods Nuclear magnetic resonance spectroscopy Osteoporosis Phosphonates Structure Zoledronic acid |
| title | Diethyl phosphonate |
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