Diethyl phosphonate

Diethyl phosphonate

Bisphosphonates are widely used in medicine and related areas, mainly for the treatment of bone diseases, such as osteoporosis. However, their synthesis is usually performed under harsh reaction conditions. In order to overcome this limitation, the present work illustrates a new synthetic route to a...

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Veröffentlicht in:MolBank 2022-08, Vol.2022 (3)
Hauptverfasser: López-Francés, Adrián, Palacios, Francisco, Maestro, Aitor, Vicario, Javier
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Care and treatment
Chemical synthesis
Enzyme inhibitors
Identification and classification
Infrared spectroscopy
Mass spectrometry
Methods
Nuclear magnetic resonance spectroscopy
Osteoporosis
Phosphonates
Structure
Zoledronic acid
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Beschreibung
Zusammenfassung:Bisphosphonates are widely used in medicine and related areas, mainly for the treatment of bone diseases, such as osteoporosis. However, their synthesis is usually performed under harsh reaction conditions. In order to overcome this limitation, the present work illustrates a new synthetic route to access the title α-aminobisphosphonate in milder reaction conditions using α-phosphorylated imines as key intermediates.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1424