MAPKERK Signalling Pathway to Explore the Mechanism of Action of Dexmedetomidine in Labour Analgesia and Its Effect on Pregnancy Outcome

Objective: Analysis of the MAPKERK signalling pathway to explore the mechanism of action of dexmedetomidine in labour analgesia and its effect on pregnancy outcome. Methods: Sixty-six pregnant women admitted to our hospital between March 2020 and January 2022 were divided into two clusters according to the different modes of anaesthesia, i.e., the control cluster and the study cluster, and were clinically observed after anaesthesia. Results: Before analgesia, none notable variation in Adr and Cor levels between the two clusters (P>0.05), while during the active period, full opening of the uterus and delivery of the fetus, Adr and Cor levels in the study cluster were bottom than those in the control cluster, and the variation was notable (P active period > delivery period. The heart rate and mean arterial pressure were stable and none hypotension or respiratory depression. None notable variation in the Apgar scores of neonates at 1min and 5min (P>0.05); before analgesia, none notable variation in HR, SBP and DBP between the two clusters (P>0.05), while during the active period, the full opening of the uterus and fetal delivery, HR, SBP and DBP in the study cluster were bottom than those in the control cluster, and the variation was notable (P0.05) before the analgesia, and the variation was notable (P