Alliance of Single Nucleotide Polymorphisms of Adiponectin with Metabolic Syndrome

Murine, and clinical studies imply that adiponectin plays an arbitrating role in obesity allied complications, and although less clearly established in humans, this suggests that molecular variants of adiponectin as a lucid candidate for unraveling the genetic basis of metabolic syndrome. To assess the pattern and alliance of metabolic syndrome with two single nucleotide polymorphism (SNP) variants, namely +276G>T (rs1501299) and + 45 T>G (rs2241766) of adiponectin in Gujarati population. Genotyping was performed by PCR-RFLP method for characterization of adiponectin gene (+276G>T and +45 T>G) polymorphism in a total of 113 cases with metabolic syndrome and 125 control participants. No departure from Hardy-Weinberg equilibrium was observed in either cases or controls for rs1501299 as well as for 2241766. An increased frequency of mutant allele of rs 1501299 (p:0084) and of rs2241766 (p:0.0313) was observed among patients affected with metabolic syndrome, which resulted in significant difference in genotypic (p