Hyperuricemia is a risk factor for Cardiovascular Risk?

Uric acid is the end product of purine metabolism in humans degraded by the hepatic enzyme, urate oxidase (uricase), to allantoin, which is freely excreted in the urine. However, during the Miocene epoch (20 to 5 million years ago), 2 parallel but distinct mutations occurred in early hominoids that rendered the uricase gene nonfunctional. Uric acid (UA) is a known endogenous scavenger, which provides a major part of the antioxidant capacity against oxidative and radical injury. The present study was conducted over a period of 1 year on outpatients attending the General Medicine Department at Narayana General Hospital, Nellore. The study was 998 subjects were taken in this study and both sexes included. Institutional ethical committee of Narayana Medical College and Hospital, Nellore, Andhra Pradesh. Uric acid levels measured in subjects. The mean and standard deviation were calculated for all the Biochemical parameter. The significance between the groups were determined using Student t- test for Equality of means. The p value of < 0.05 was considered significant. The two-tailed p value is less than 0.0001, By conventional criteria, this difference is considered to be extremely statistically significant. Confidence interval: The hypothetical mean is 1.0000 and the actual mean is 6.4600. The difference between these two values is 5.4600. The 95% confidence interval of this difference from 5.3489 to 5.5711. Intermediate values used in calculations; t = 96.4583, df = 999 and standard error of difference = 0.057. Evidence regarding the relationship between high serum uric acid concentrations and hypertension and other cardiovascular risk factors is extensive. Furthermore, current data also suggest that hyperuricemia could increase the risk of developing renal and CV disease.