Microalbuminuria as a novel marker of CKD in relation with other Complications

Diabetic mellitus (DM) remains a public health concern world wide as its complications have been a major cause of morbidity and mortality. The chronic complication of DM includes microvascular complications (Nephropathy, Retinopathy and Neuropathy) and Macrovascular complications (Coronary artery disease, Cerebral vascular disease and Peripheral arterial disease) (1). Out of these complications Diabetic nephropathy has generally been viewed as a descending path from normoalbuminuria (NA) to end stage renal diseases (ESRD) through an intermediate stage marked by microalbuminuria (MA) and overt proteinuria. Major clinical manifestation of diabetic nephropathy are albuminuria. MA is consider an early stage diabetic nephropathy. The prevalence of MA in patients with type II diabetes has been reported from 20% to 61%. Keeping in view the prevalence of diabetic complications the present study was planned to investigate the status of MA in individuals having CKD and other complication. Study was conducted in Department of Biochemistry in collaboration with Department of Medicine ASCOMS Jammu and Department of Biochemistry, GMC, Amritsar. Various biochemical parameters were investigated in the individuals suffering from type II diabetes. All the individuals were divided into groups depending upon the Albumin creatinine ratio and type of complications. Out of 200 individuals 42.5% belonged to microalbuminuria group. In this group 67.05% had normal renal status while 32.94% had abnormal renal status. Thus microalbuminuria is more observed in individuals having normal urea creatinine. Complications were also observed more in normal renal status then abnormal renal status individuals.