Adenosine Deaminase Activity In Subjects With Altered And Normal Liver Function Profile Test

INTRODUCTION: Adenosine Deaminase (ADA) is a nonspecific marker for cellular immunity, is raised in diseases eliciting a cell-mediated immune response. High serum ADA activities were observed in patients with different liver diseases. In this study we aim to determine the association of serum ADA and transaminases levels in liver disease patients and normal control. Methodology: In this comparative cross sectional study 80 subjects, 40 with liver disease and 40 without liver disease were enrolled. Blood samples were drawn and analysis was done. Liver function profile was done by Autoanalyzer (cobas 311, Germany) and ADA activity was measured by Giusti and Gallanti method. Independent t test and Mann Whitney U test for association; Pearson's correlation and Spearman's Rho for correlation study. Multiple linear regression model use for independent association of the variable with ADA. P