Thyroid Profile In Diabetes With or Without Complication

INTRODUCTION- Diabetes Mellitus is a result of social influence and changing lifestyle. It is characterized by absolute or relative insulin deficiency in insulin secretion and/or insulin associated with chronic hyperglycemia. Diabetes and thyroid disorders have been shown to mutually influence each other and associated between both conditions have been long reported. Patients with Type2 DM are more prone to thyroid disorders. Hypothyroidism is them leads to an aggravation of microvascular complications (nepropathy, retinopathy, neuropathy). Diabetic patients with hypothyroidism are at an increased risk of cardiovascular disease. Free and total T3 and T4 concentrations are usually normal or low in patients with nephropathy. Insulin an anabolic hormone enhances the levels of fT4 while it suppresses the levels of T3 by inhibiting hepatic conversion of T4 to T3. MATERIAL AND METHODS-The present study is being conducted in Department of Biochemisrty in association with Department of Medicine GMC ASR. 100 patients suffering from type 2 Diabetes with complications were recruited for the past study and 100 age and sex matched individuals viewed as controls. RESULTS-It was observed that mean [+ or -] S.E levels of free T3 were 2.3 [+ or -] 0.19, T4 1.6 [+ or -] 0.06 and TSH is 2.3 [+ or -] 0.44. Level of fT3 and fT4 were significantly reduced compared to controls. Further the study group was classified depending on the type of complications ie microvascular and macrovascular and it was observed that in patients with macrovascular complications levels of TSH were more whereas in patients with microvascular complications levels of fT3 and fT4 were less. CONCLUSIONS- Patients with Type 2 DM with increased levels of TSH are more prone to diabetic complication. KEY WORDS: Diabetes Mellitus, nepropathy, retinopathy, neuropathy, TSH