Oxidative Stress and Paraoxanase Status in Ischemic Stroke Patients

Stroke is the leading cause of mortality worldwide. Oxidative stress is a characteristic of ischemic stroke. The event results in generation of free radicals leading to promotion of lipid peroxidation. Paraoxanase prevents oxidative modification of LDL. The aim of this study was to investigate the association between ox-LDL and Paraoxanase status in ischemic stroke patients by determining whether oxidative stress is an useful marker in ischemic stroke patients. The present study included 60 patients of ischemic stroke and 60 controls. All patients were in the age group of 55-85 years and admitted in ICU of base hospital attached to ACMS, Delhi. Plasma ox-LDL was estimated by ELISA method and serum Paraoxanase was measured by ELICO Spectrophotometer. Plasma levels of ox-LDL increased in stroke patients as compared to controls (P < 0.001) serum levels of Paraoxanase activity decreased in stroke patients as compared to controls (P < 0.001). Results indicate the presence of inflammatory response associated with stroke. We hypothesised that elevated ox-LDL levels and lower Paraoxanase activity may contribute for the development of oxidative stress. The present study was carried out to emphasize the importance of these markers for early diagnosis and therapeutic interventions in ischemic stroke patients.