Response of Isolated Rat Heart to [[alpha].sub.2]-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period

Response of Isolated Rat Heart to [[alpha].sub.2]-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period

We studied the effect of [[alpha].sub.2]-adrenoreceptor activation after preliminary If-current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of [[alpha].sub.2]-adrenoreceptors against the background of application of If b...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2022-11, Vol.174 (1), p.22
Hauptverfasser: Bugrov, R.K, Kuptsova, A.M, Ziyatdinova, N.I, Zefrov, T.L
Format: Artikel
Sprache:eng
Schlagworte:
Dexmedetomidine
Heart attack
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Zusammenfassung:We studied the effect of [[alpha].sub.2]-adrenoreceptor activation after preliminary If-current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of [[alpha].sub.2]-adrenoreceptors against the background of application of If blocker ZD7288 in concentrations of [10.sup.-9] and [10.sup.-5] M decreased myocardial inotropy in isolated rat hearts by 50 and 39% (p
ISSN:0007-4888
DOI:10.1007/s10517-022-05640-x