Blood Biochemical Markers for Endemic Fluorosis: A Case Control Study

Fluoride in ground water is a major health problems not only Rajasthan but also worldwide. The prolonged exposure of fluoride can accumulate in the body and it may cause significant damage to health like dental and skeletal Fluorosis. In the present study we attempt to investigate biochemical markers for diagnosis of early Fluorosis. In the present study, 150 fluorotic patient (age 20 to 40 years) were recruited for the assessment of biochemical markers and 150 healthy age and sex matched controls were selected. Blood samples were taken for fluoride estimations, hematological test and oxidative stress markers. The concentration of fluoride and lipid per oxidation was increased while antioxidants levels SOD, CAT and glutathione were reduced in subjects as compared with the controls. In addition the number of WBC and RBC were changed along with the packed cell volume. The concentration of Hb and heart rate were also changed in subjects. On the basis of result it may conclude that fluoride causes increased lipid peroxide and decreased antioxidant levels and changed hematological profiles. The spectrum of analysis could be useful for the assessment of early Fluorosis as primary symptoms.