Study of HDL-Cholesterol:LDL-Cholesterol in Hypothyroidism Patients

Thyroid hormones effect metabolic processes in the body. Thyroid hormones significantly affect lipoprotein metabolism and thus abnormal thyroid function is suggested to have a causative role in cardiovascular disease. Objective was to evaluate HDL-cholesterol:LDL-cholesterol ratio in hypothyroid patients and to compare it with age and sex matched healthy controls. This was a cross sectional study conducted in the Department of Biochemistry, Pt B D Sharma, PGIMS, Rohtak. Thirty cases of hypothyroidism (subclinical and overt) and thirty age and sex matched healthy controls (euthyroid) were enrolled after informed consent and their fasting serum samples were analysed for serum triglyceride, total cholesterol and HDL cholesterol levels by enzymatic methods in autoanalyser and LDL cholesterol was calculated (Friedwald's formula) and HDL- cholesterol:LDL-cholesterol ratio was calculated. The mean values of HDL- cholesterol:LDL-cholesterol in hypoyhyroid patients was significantly lower as compared to that in controls with P