Insight to Preeclampsia- An Association of Platelet Factor-4 and Nitric oxide

Platelets play a crucial role in the pathophysiologic mechanisms of preeclampsia. Platelet-derived Nitric Oxide (NO) is known to inhibit platelet activation and prevent thrombus formation. Impaired platelet NO production increased P-selectin expression on the thrombocyte surface resulting in enhanced platelet adhesion to monocytes and elevated expression of tissue factor, an initiator of coagulation. Our purpose was to investigate the correlation between Platelet nitric oxide and Platelet Factor-4. Total of 500 subjects were taken (200-control subjects, including healthy pregnant females & 300 study subjects diagnosed with preeclampsia) from the wards of SSKH & LHMC, with informed consent from subjects, after approval by institutional ethical committee. The blood was taken and according to the protocol the Platelet rich plasma was taken for the detection of PF4 & NO by ELISA & spectro-photometrically respectively. In the present study significantly high levels of PF4 (P