Study of Anthropometric, Hormonal and Biochemical Profile Among Obese and Non Obese Women with Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder characterized by chronic anovulation, hyperandrogenism, multiple small subcapsular cystic follicles in the ovary. PCOS is associated with metabolic abnormalities--insulin resistance, metabolic syndrome, dyslipidemia, besides increased risk for cardiovascular diseases. Earlier, it was believed that only obese women are susceptible to PCOS. Recent evidence shows that many non -obese women are also developing PCOS. To investigate the anthropometric, biochemical, hormonal profile among obese and non--obese women with PCOS.150 women with PCOS, divided into two sub--groups depending on body mass index (BMI) ( 30 kg/[m.sup.2]), along with 75 healthy age--matched control women were studied. Serum lipid profile, fasting blood glucose, fasting insulin levels, thyroid profile, luteinizing hormone, follicle stimulating hormone, and prolactin were measured. Statistical analysis was done using SPSS software 20.0. There were about 30% of PCOS women with normal BMI. High fasting blood glucose and insulin levels, high cholesterol, triglyceride, LDL, VLDL and lower HDL levels were found in both obese and non obese PCOS compared to control women. Similarly lower FSH level, higher LH levels and LH/FSH ratio, mild to severe hyperprolactinaemia was found in the both the groups when compared to controls. There was significant difference in lipid profile levels and gonadotropin hormone levels. Obesity is a common finding among women with PCOS. There was some difference with respect to biochemical and hormonal profile in obese and non- obese PCOS women.