SERUM ADENOSINE DEAMINASE AND ITS ISOENZYME ACTIVITY IN ASTHMA

SERUM ADENOSINE DEAMINASE AND ITS ISOENZYME ACTIVITY IN ASTHMA

Asthma is a chronic inflammatory disorder of airways causing variable airflow obstruction. In asthma, adenosine levels increase; this may then interact with mast cells, lymphocytes and monocytes-macrophages via its receptors to cause inflammation. Adenosine is converted to inosine by Adenosine deami...

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Veröffentlicht in:Indian journal of clinical biochemistry 2022-05, Vol.27 (S1), p.S45
Hauptverfasser: Sharma, J, Menon, B.K, Vijayan, V.K, Bansal, S.K
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine
Analysis
Asthma
Isoenzymes
Medical research
Medicine, Experimental
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Zusammenfassung:Asthma is a chronic inflammatory disorder of airways causing variable airflow obstruction. In asthma, adenosine levels increase; this may then interact with mast cells, lymphocytes and monocytes-macrophages via its receptors to cause inflammation. Adenosine is converted to inosine by Adenosine deaminase (ADA, E.C.3.5.4.4). The increase in adenosine may be due to decrease in ADA activity. There are two isoenzymes of ADA in serum; ADA1 and ADA2. The objective of this study was to examine the changes in activity of ADA and its isoenzyms in serum of asthma patients and correlate them with the severity of airflow obstruction.
ISSN:0970-1915