SIGNIFICANCE OF SERUM URIC ACID LEVEL AND ITS RELATION TO OUTCOME IN HYPERTENSIVE DISORDER OF PREGNANCY

Pregnancy induced hypertension is a multisystemic syndrome and a leading cause of maternal and fetal morbidity and mortality. This study comprised 125 cases of pregnancy induced hypertension (PIH) and 125 healthy pregnant women with normal blood pressure as a control group. They were primarily diagnosed for PIH by clinical examination followed by Biochemical investigations and their fetal outcomes were observed. Mean Uric acid level was 3.8 [+ or -] 1.0 mg/dl in the normotensive group and 7.4 [+ or -] 2.2 mg/dl in (PIH) case group, with a p value of < 0.001. Serum urea was 26.5 [+ or -] 9.1 mg/dL in the normotensive group and 23.4 [+ or -] 6.6 mg/dl in PIH case group, with a p value of 0.002. Serum creatinine was 0.7 [+ or -] 0.4 mg/dL in the normotensive group and 0.6 [+ or -] 0.2 mg/dl in PIH case group, with a p value of 0.003. Proteinuria is also present in the case group in the patients of preeclampsia and eclampsia but it is not present in the normal healthy pregnant woman. But Blood urea and Serum Creatinine levels in both cases and controls is within normal limits. This finding rules out any renal disorder. In the present study we found that Patient with high serum uric acid levels are at risk of worst fetal outcome as compare to those who have normal serum uric acid levels. Thus high serum uric acid level in patients of pregnancy induced hypertension can be used as marker for fetal outcome.