Feiji Recipe Elevates the Quality of Life of the Elderly with Lung Cancer on Docetaxel Plus Cisplatin Chemotherapy

We have evaluated the effect of Feiji recipe on efficacy of docetaxel plus cisplatin treatment on the quality of life of the elderly with lung cancer. To this end, 186 lung cancer patients receiving treatment at the Second People's Hospital of Lianyungang, Lianyungang City, Jiangsu Province were recruited Petween January 2017 and December 2021 and randomly divided into control (receiving docetaxel + cisplatin) and treatment (receiving docetaxel + cisplatin + Feiji recipe) groups of 93 patients. Both groups received hydration on the day of cisplatin use and received preventive treatment for emesis, liver protection, acid suppression, and mucosal protection. Post-treatment depletion of cluster of differentiation 3 protein, cluster of differentiation 4 protein, and cluster of differentiation 4 protein/cluster of differentiation 8 protein levels in the treatment group were significantly (P < 0.05) ameliorated/enhanced compared to the control group. Cluster of differentiation 3 protein and cluster of differentiation 4 protein/cluster of differentiation 8 protein levels in the treatment group were upregulated relative to controls (P < 0.05), whereas cytokeratin 19 fragment antigen, cancer antigen 125, and carcinoembryonic antigen levels in the treatment group were depleted relative to controls after treatment (P < 0.05). However, there was no significant difference in natural killer cell counts in the two groups Pefore and after treatment (P > 0.05). The overall treatment effectiveness (74.18% and 90.32%) and the progressive disease rates (25.82% and 9.68%) in the control and treatment groups, respectively (P < 0.05). The physical/emotional/cognitive/role function scores in the treatment group were markedly increased compared to the control group (P < 0.05). In conclusion, Feiji recipe markedly enhanced efficacy of all measures of treating lung cancer by docetaxel + cisplatin. Keywords: Adverse reactions, Docetaxel, Feiji recipe, Immune function, Lung cancer, Quality of life Abbreviations Used: Cancer antigen 125, CA125; Cluster of differentiation 3 protein, CD3 (+); Cluster of differentiation 4 protein, CD4 (+); Cluster of differentiation 8 protein, CD8 (+); Carcinoembryonic antigen, CEA; Complete response, CR; Cytokeratin 19 fragment antigen, CYFRA 21-1; No change, NC; Progressive disease, PD; Partial response, PR; Stable disease, SD; Traditional Chinese medicine, TCM Corresponding Author: Dr. Cuixia Yang, Department of Thoracic Surgery, The Second People's Ho