Composition Development and Experimental Study of the Liposomal form of an Antiarrhythmic Drug

The aim of the work was to obtain a liposomal form of the complex of the antiarrhythmic drug allapinin (lappaconitine hydrobromide) and the monoammonium salt of glycyrrhizic acid (MASGA) and to study the release kinetics of allapinin/MASGA into a medium modeling the salt composition and pH of blood serum. As a result, liposomes containing the allapinin/MASGA complex were obtained. The most preferred ratio of phosphatidylcholine and cholesterol in the liposomes was found to be 5:2. The release kinetics of the lappaconitine hydrobromide/MASGA complex from the liposomes were studied in a medium simulating the salt composition and pH of blood serum [1.5 mMsodium phosphate (pH 7.4) + 0.15MNaCl] and showed that 32% of lappaconitine was released in the first 30 min. The release rate stabilized within 2 h after administration and practically did not drop in the next 3 h of the experiment. This behavior showed good prospects for using liposomes loaded with the allapinin/MASGA complex as a prolonged release drug form.