L-glutamine Supplemented Nutrition Alleviates Damage Caused by Corrosive Esophagitis in Rats/L-glutamin Destekli Beslenme Ratlarda Koroziv Ozefajit Hasarini Azaltmaktadir

Objective: The primary goal in the treatment of corrosive esophagitis (CE) is to control inflammation and scar reactions. L-glutamine (Gln) is beneficial for the integrity of the intestinal mucosal epithelium and is an amino acid that promotes mature collagen growth. This study was designed to demonstrate the positive results of Gln on injury in corrosive esophagitis. Method: Thirty Sprague-Dawley rats were used in the study. They were divided into 3 groups. CE was formed by dripping 20% sodium hydroxide into the distal esophagus in both groups except the control group (n=10). First group (n=9) was left untreated, while the other group (n=9) was fed orally with the addition of 1 g/kg Gln once a day for 21 days. All rats were sacrificed after 3 weeks. Esophagus of treated and other group rats were examined under light microscope to evaluate collagen deposition, histological damage score and stenosis index. Results: Excess submucosal collagen, muscularis mucosal damage, inflammation and ulceration, which are among the histological damage score parameters, were significantly higher in the untreated group than in the Gln group (p=0.005, p=0.015, p=0.001, respectively). The stenosis index was significantly different (p=0.013). The group treated with Gln had inflammation but no ulceration and necrosis. Conclusion: Our experimental animal study suggests that Gln in nutrition reduces damage in the esophageal mucosa, slows down or partially stops the cellular destruction process that causes stenosis, Keywords: Caustics, corrosives, esophagitis, L-glutamine, esophagial stricture Amac: Koroziv ozofajit tedavisinde birincil amac enflamasyon ve skar reaksiyonlarini baskilayarak kontrol etmektir. L-glutamin, bagirsak mukozal epitelinin butunlugunu ve matur kollajen buyumesini destekleyen bir amino asittir. Bu calisma, L-glutamin'in korozif ozofajitte olusan ozofagial hasar uzerindeki olumlu sonuclarini degerlendirmek icin tasarlanmistir. Yontem: Calismada 30 adet Sprague-Dawley cinsi sican kullanildi. Uc gruba ayrildilar. Kontrol grubu (n=10) haric her iki grupta da distal ozofagusa %20 NaOH (sodyum hidroksit) damlatilarak korozif ozofajit olusturuldu. Birinci grup (n=9) tedavi edilmeden birakildi, diger grup (n=9) 21 gun boyunca gunde bir kez 1 g/kg L-glutamin ilave edilerek agizdan beslendi. Tum sicanlar 3 hafta sonra sakrifiye edildi. Kollajen birikimi, histolojik hasar skoru ve stenoz indeksini degerlendirmek icin tedavi edilen ve diger grup sicanlarin yemek borusu