Abnormal Uterine Bleeding Associated with Bupropion: A Case Report/Bupropion ile Iliskili Anormal Uterin Kanama: Olgu Sunumu

In the literature, many cases of abnormal uterine bleeding associated with selective serotonin reuptake inhibitors have been reported as a side effect of antidepressant treatment. However, abnormal uterine bleeding associated with bupropion, a norepinephrine-dopamine reuptake inhibitor, has been reported in only two case studies to date. A 28-year-old, oligomenorrheic female patient was admitted to the psychiatry department with the symptoms of depression. The patient was diagnosed with major depression and bupropion 150 mg/day was prescribed. After the initiation of the treatment, the patient experienced mild-to-moderate uterine bleeding, which was resolved with the discontinuation of the drug. In the patient's anamnesis, it was learned that the same side effect had developed with the previous bupropion treatment. A comprehensive examination of the patient suggested that this adverse effect could strongly be associated with bupropion. This case supports the view that antidepressants can cause bleeding abnormalities, in particular vaginal bleeding caused by bupropion usage. Physicians who prescribe bupropion should carefully follow up their patients to identify such adverse effects. Keywords: Abnormal uterine bleeding, adverse effect, bupropion, case reports Literaturde, antidepresan tedavisi yan etkisi olarak selektif serotonin reuptake inhibitorleri ile iliskili cok sayida anormal uterin kanama olgusu bildirilmistir. Bir norepinefrin-dopamin geri alim inhibitoru olan bupropion ile iliskili anormal uterin kanama bu tarihe kadar sadece iki olgu sunumunda bildirilmistir. Yirmi sekiz yasinda, oligomenoreik kadin hasta, depresyon belirtileri ile klinigimize basvurdu. Hastaya major depresyon tanisi konuldu ve bupropion 150 mg/gun recete edildi. Tedavinin baslamasindan sonra hastada, ilacin kesilmesi ile duzelen hafif-orta derecede duzensiz uterin kanama gelisti. Hastanin anamnezinde daha onceki bupropion tedavisi ile de ayni yan etkinin gelismis oldugu bilgisi edinildi. Kapsamli bir inceleme sonrasinda, bu yan etkinin bupropion ile guclu bir sekilde iliskili olabilecegi dusunuldu. Bu olgu, antidepresanlarin kanama anormalliklerine, ozellikle bupropion kullanimina bagli vajinal kanamalara neden olabilecegi gorusunu desteklemektedir. Bupropion recetesi yazan doktorlar, bu tur yan etkileri belirlemek icin hastalarini dikkatle izlemelidirler. Anahtar kelimeler: Anormal uterin kanama, bupropion, olgu sunumu, yan etki